{"id":2053,"date":"2023-07-13T08:17:33","date_gmt":"2023-07-13T00:17:33","guid":{"rendered":""},"modified":"2023-07-13T08:17:33","modified_gmt":"2023-07-13T00:17:33","slug":"","status":"publish","type":"post","link":"http:\/\/www.idea2003.com\/dongtai\/2053.html","title":{"rendered":"\u4e0d\u8fd0\u52a8\u4e5f\u80fd\u7626\uff0c\u9a6c\u65af\u514b\u90fd\u5728\u7528\u7684\u51cf\u80a5\u795e\u836f\u662f\u4ec0\u4e48\u6765\u5934\uff1f"},"content":{"rendered":"<p class=\"art-description\">\u4eba\u7c7b\u6b63\u5728\u5b9e\u73b0\u4e00\u76f4\u4ee5\u6765\u7684\u68a6\u60f3\uff1a\u80e1\u5403\u6d77\u585e\u4e14\u4e0d\u80d6\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/www.idea2003.com\/wp-content\/uploads\/2023-07-13\/433f5abf06cae5f23e377f5736b9239c.jpg\" alt=\"\u56fe\u7247\" title=\"\u4e0d\u8fd0\u52a8\u4e5f\u80fd\u7626\uff0c\u9a6c\u65af\u514b\u90fd\u5728\u7528\u7684\u51cf\u80a5\u795e\u836f\u662f\u4ec0\u4e48\u6765\u5934\uff1f\u63d2\u56fe\" \/><\/p>\n<p>\u5fae\u65b0\u521b\u60f3\uff08ID\uff1aichuangyebang\uff09\u539f\u521b<\/p>\n<p>\u4f5c\u8005\u4e28\u738b\u827a<\/p>\n<p>\u7f16\u8f91\u4e28\u6d77\u8170<\/p>\n<p>\u56fe\u6e90\u4e28\u56fe\u866b\u521b\u610f<\/p>\n<p>\u201c\u73b0\u5728\u597d\u591a\u4eba\u90fd\u6253\u8fd9\u4e2a\u9488\u51cf\u80a5\u3002\u6bcf\u5468\u6253\u4e00\u6b21\uff0c\u4e00\u4e2a\u67084000\u591a\u5757\uff0c\u8ddf\u627e\u4e00\u4e2a\u5065\u8eab\u79c1\u6559\u7684\u4ef7\u94b1\u4e5f\u5dee\u4e0d\u591a\uff0c\u8fd8\u4e0d\u7528\u771f\u7684\u5065\u8eab\u3002\u6253\u8fd9\u4e2a\u9488\u7684\u4eba\u57fa\u672c\u90fd\u7626\u4e0b\u6765\u4e86\uff0c\u6548\u679c\u975e\u5e38\u660e\u663e\u3002\u201d<\/p>\n<p>\u201c\u8fd9\u4e2a\u9488\u201d\u5c31\u662fWegovy\uff0c\u5373\u8bfa\u5fb7\u8bfa\u5fb7\u7684\u53f8\u7f8e\u683c\u9c81\u80bd\u3002\u9a6c\u65af\u514b\u4e5f\u66fe\u53d1\u63a8\u79f0\uff0c\u9760\u6253Wegovy\u7626\u4e0b\u676518\u65a4\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/www.idea2003.com\/wp-content\/uploads\/2023-07-13\/2bfd54d0b27a241fec4f36021fe6d1d7.png.jpeg\" alt=\"\u56fe\u7247\" title=\"\u4e0d\u8fd0\u52a8\u4e5f\u80fd\u7626\uff0c\u9a6c\u65af\u514b\u90fd\u5728\u7528\u7684\u51cf\u80a5\u795e\u836f\u662f\u4ec0\u4e48\u6765\u5934\uff1f\u63d2\u56fe1\" \/><\/p>\n<p>Gila monster\uff0c\u4e2d\u6587\u901a\u5e38\u8bd1\u4f5c\u5e0c\u62c9\u6bd2\u8725\uff0c\u662f\u56fd\u5916\u4e00\u4e9b\u8725\u8734\u517b\u6b96\u7231\u597d\u8005\u7684\u7ec8\u6781\u68a6\u60f3\u3002\u5e0c\u62c9\u6bd2\u8725\u98df\u91cf\u60ca\u4eba\uff0c\u4e00\u6b21\u53ef\u4ee5\u5403\u4e0b\u81ea\u8eab\u4f53\u91cd\u4e00\u534a\u91cd\u91cf\u7684\u98df\u7269\u3002<\/p>\n<p>\u4ece\u5e0c\u62c9\u6bd2\u8725\u7684\u6bd2\u6db2\u4e2d\u63d0\u53d6\u7684Exendin-4\uff0c\u4f5c\u4e3a\u5546\u4e1a\u5316\u7c7bGLP-1\u836f\u7269\u7684\u201c\u8d77\u6e90\u201d\uff0c\u6b63\u5728\u5e2e\u52a9\u4eba\u7c7b\u5b9e\u73b0\u4e00\u76f4\u4ee5\u6765\u7684\u68a6\u60f3\uff1a\u50cf\u5e0c\u62c9\u6bd2\u8725\u90a3\u6837\uff0c\u80e1\u5403\u6d77\u585e\u4e14\u4e0d\u80d6\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/www.idea2003.com\/wp-content\/uploads\/2023-07-13\/9b73fbac9f7f8360b91445c6226831fd.jpg\" alt=\"\u56fe\u7247\" title=\"\u4e0d\u8fd0\u52a8\u4e5f\u80fd\u7626\uff0c\u9a6c\u65af\u514b\u90fd\u5728\u7528\u7684\u51cf\u80a5\u795e\u836f\u662f\u4ec0\u4e48\u6765\u5934\uff1f\u63d2\u56fe2\" \/><\/p>\n<p><em>\u9a6c\u65af\u514b\u51cf\u80a5\u524d\u540e\u5bf9\u6bd4\u56fe<\/em><\/p>\n<p><img decoding=\"async\" src=\"http:\/\/www.idea2003.com\/wp-content\/uploads\/2023-07-13\/90628d87ca66fa766fc718dfebf9c9fa.png.jpeg\" alt=\"\u56fe\u7247\" title=\"\u4e0d\u8fd0\u52a8\u4e5f\u80fd\u7626\uff0c\u9a6c\u65af\u514b\u90fd\u5728\u7528\u7684\u51cf\u80a5\u795e\u836f\u662f\u4ec0\u4e48\u6765\u5934\uff1f\u63d2\u56fe3\" \/><\/p>\n<h2 style=\"text-align: center;\"><strong>GLP-1\u7684\u8d77\u6e90<\/strong><\/h2>\n<p>1971\u5e74\uff0c\u79d1\u5b66\u5bb6\u4ece\u5c0f\u80a0\u7c98\u819c\u4e2d\u5206\u79bb\u51fa\u7b2c\u4e00\u79cd\u80a0\u4fc3\u80f0\u5c9b\u7d20\uff0c\u4ed6\u4eec\u53d1\u73b0\u8fd9\u79cd\u6fc0\u7d20\u4e0d\u4ec5\u53ef\u4ee5\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u5206\u6ccc\uff0c\u66f4\u662f\u5177\u6709\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\uff0c\u53ea\u6709\u5f53\u8840\u7cd6\u5347\u9ad8\u65f6\uff0c\u624d\u80fd\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u7684\u5206\u6ccc\u3002\u4e5f\u56e0\u6b64\uff0c\u8fd9\u79cd\u80a0\u4fc3\u80f0\u5c9b\u7d20\u88ab\u547d\u540d\u4e3a\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\u4fc3\u80f0\u5c9b\u7d20\u5206\u6ccc\u591a\u80bd\uff08GIP\uff09\uff0c\u4eba\u7c7b\u5728\u8fdb\u98df\u540e\u4ece\u80a0\u9053\u4e2d\u68c0\u6d4b\u51fa\u80f0\u5c9b\u7d20\u5347\u9ad8\u7684\u73b0\u8c61\u4e5f\u88ab\u79f0\u4e3a\u80a0\u4fc3\u80f0\u5c9b\u7d20\u6548\u5e94\u3002<\/p>\n<p>GIP\u867d\u597d\uff0c\u4f46\u5b83\u5e76\u4e0d\u80fd\u523a\u6fc02\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\u3002\u4e8e\u662f\uff0c1985\u5e74\uff0c\u79d1\u5b66\u5bb6\u4ece\u80a0\u9053\u9ecf\u819c\u4e2d\u5206\u79bb\u63d0\u53d6\u51fa\u4e86\u7b2c\u4e8c\u79cd\u80a0\u4fc3\u80f0\u5c9b\u7d20\u2014\u2014\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\uff08GLP-1\uff09\uff0c\u5b83\u662f\u4e00\u79cd\u7531\u80f0\u9ad8\u8840\u7cd6\u7d20\u7cd6\u539f\u884d\u751f\u51fa\u6765\u7684\u4e00\u79cd\u80bd\u7c7b\u6fc0\u7d20\uff0c\u4e3b\u8981\u7531\u80a0\u9053\u548c\u8111\u5e72\u4ea7\u751f\uff0c\u5b83\u4e5f\u5177\u6709\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\uff0c\u548cGIP\u4e00\u8d77\u5171\u540c\u4ea7\u751f\u80a0\u4fc3\u80f0\u5c9b\u7d20\u6548\u5e94\u3002<\/p>\n<p>GLP-1\u4f5c\u7528\u4e8eGLP-1R\u9776\u70b9\uff0c\u8be5\u9776\u70b9\u5206\u5e03\u5728\u80f0\u817a\uff08\u03b1\u7ec6\u80de\u3001\u03b2\u7ec6\u80de\uff09\u3001\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u3001\u80c3\u80a0\u9053\u53ca\u5fc3\u8840\u7ba1\u7b49\u591a\u4e2a\u7ec4\u7ec7\u4e2d\uff0c\u80f0\u5c9b\u7d20\u03b2\u7ec6\u80de\u4e2d\u7684GLP-1R\u6fc0\u6d3b\u65f6\u4f1a\u523a\u6fc0\u80f0\u5c9b\u7d20\u5206\u6ccc\u3001\u6291\u5236\u80f0\u5c9b\u03b1\u7ec6\u80de\u91ca\u653e\u80f0\u9ad8\u8840\u7cd6\u7d20\u3001\u964d\u4f4e\u9910\u540e\u8840\u7cd6\uff0c\u540c\u65f6\u8fd8\u80fd\u51cf\u7f13\u80c3\u6392\u7a7a\uff0c\u6291\u5236\u98df\u6b32\uff0c\u4ece\u800c\u8d77\u5230\u964d\u7cd6\u3001\u51cf\u80a5\u7684\u4f5c\u7528\u3002<\/p>\n<p>GLP-1\u5f88\u5feb\u5c31\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u8bc1\u660e\u4e86\u5f3a\u5927\u7684\u6297\u7cd6\u5c3f\u75c5\u4f5c\u7528\u3002<\/p>\n<p>\u7136\u800c\uff0c\u7531\u4e8eGLP-1\u5728\u4eba\u4f53\u5185\u7684\u534a\u8870\u671f\u6781\u77ed\uff0c\u5206\u6ccc2-3\u5206\u949f\u540e\u5c31\u4f1a\u88ab\u4e8c\u80bd\u57fa\u80bd\u9176\uff08DPP4\uff09\u964d\u89e3\uff0c\u5373\u4f7f\u5916\u6e90\u6027\u7ed9\u4e88GLP-1\uff0c\u4e5f\u540c\u6837\u5f88\u5feb\u4f1a\u88abDPP4\u964d\u89e3\u3002\u4e8e\u662f\u4eba\u4eec\u8bbe\u8ba1\u4e86\u4e8c\u80bd\u57fa\u80bd\u9176\u6291\u5236\u5242\uff0c\u5b83\u53ef\u4ee5\u964d\u4f4eGLP-1\u5728\u4f53\u5185\u7684\u964d\u89e3\uff0c\u4ece\u800c\u8fbe\u5230\u964d\u7cd6\u4f5c\u7528\u3002<\/p>\n<p>1992\u5e74\uff0c\u5185\u5206\u6ccc\u5b66\u4e13\u5bb6John Eng\u535a\u58eb\u4ece\u5e0c\u62c9\u6bd2\u8725\uff08Gila Monster\uff09\u7684\u6bd2\u6db2\u4e2d\u53d1\u73b0\u4e86\u4e00\u79cd\u65b0\u6210\u5206\uff0c\u5c06\u5176\u547d\u540d\u4e3aExendin-4\u3002<\/p>\n<p>Exendin-4\u8ddfGLP-1\u7684\u6027\u8d28\u5f88\u50cf\uff0c\u80fd\u591f\u523a\u6fc0\u80f0\u5c9b\u7d20\u7684\u5206\u6ccc\uff0c\u4e14\u964d\u89e3\u901f\u5ea6\u6bd4GLP-1\u6162\u5f97\u591a\u3002<\/p>\n<p>1996\u5e74\uff0cJohn Eng\u535a\u58eb\u4e0eAmylin\u516c\u53f8\u8fbe\u6210\u4e86\u5408\u4f5c\u534f\u8bae\uff0c\u968f\u540eAmylin\u4e0e\u793c\u6765\uff08Eli Lilly\uff09\u8fbe\u6210\u4e86\u5171\u540c\u7814\u53d1\u534f\u8bae\uff0c\u63a8\u51fa\u4e86\u827e\u585e\u90a3\u80bd\uff08Exenatide\/ BYETTA\uff09\uff0c\u4e8e2005\u5e74\u83b7\u5f97\u4e86FDA\u6279\u51c6\uff0c\u6210\u4e3a\u4e86GLP-1\u7c7b\u4f3c\u7269\u7684\u9996\u521b\u65b0\u836f\uff08First-in-class\uff09\uff0c\u7528\u4e8e2\u578b\u7cd6\u5c3f\u75c5\u7684\u8f85\u52a9\u6cbb\u7597\u3002<\/p>\n<p>\u968f\u540e\uff0c\u5229\u62c9\u9c81\u80bd\uff08Liraglutide\uff09\u3001\u8d1d\u90a3\u9c81\u80bd\uff08\u7531\u4ec1\u4f1a\u751f\u7269\u7814\u53d1\uff09\u3001\u5ea6\u62c9\u7cd6\u80bd\uff08Dulaglutide\uff09\u3001\u53f8\u7f8e\u683c\u9c81\u80bd\uff08Semaglutide\uff09\u7b49GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u5148\u540e\u9762\u5e02\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/www.idea2003.com\/wp-content\/uploads\/2023-07-13\/99efaed1d45333bfc70b003bfecb1a5f.jpg\" alt=\"\u56fe\u7247\" title=\"\u4e0d\u8fd0\u52a8\u4e5f\u80fd\u7626\uff0c\u9a6c\u65af\u514b\u90fd\u5728\u7528\u7684\u51cf\u80a5\u795e\u836f\u662f\u4ec0\u4e48\u6765\u5934\uff1f\u63d2\u56fe4\" \/><\/p>\n<p><em>\u56fe\u6e90\uff1a\u56fe\u866b\u521b\u610f<\/em><\/p>\n<p><img decoding=\"async\" src=\"http:\/\/www.idea2003.com\/wp-content\/uploads\/2023-07-13\/37509420b632dfc942d2e65f3935f661.png.jpeg\" alt=\"\u56fe\u7247\" title=\"\u4e0d\u8fd0\u52a8\u4e5f\u80fd\u7626\uff0c\u9a6c\u65af\u514b\u90fd\u5728\u7528\u7684\u51cf\u80a5\u795e\u836f\u662f\u4ec0\u4e48\u6765\u5934\uff1f\u63d2\u56fe5\" \/><\/p>\n<h2 style=\"text-align: center;\"><strong>\u53cc\u5b50\u661f\u5ea7<\/strong><\/h2>\n<p>\u5728\u201c\u795e\u836f\u201d\u53f8\u7f8e\u683c\u9c81\u80bd\u51fa\u73b0\u4e4b\u524d\uff0cGLP-1\u9886\u57df\u7684\u4e3b\u8981\u964d\u7cd6\u836f\u7269\u662f\u5229\u62c9\u9c81\u80bd\u548c\u5ea6\u62c9\u7cd6\u80bd\u3002\u800c\u8fd9\u4e24\u6b3e\u836f\u80cc\u540e\u7684\u7814\u53d1\u8005\uff0c\u662fGLP-1\u9886\u57df\u7814\u53d1\u5b9e\u529b\u6700\u7a81\u51fa\u7684\u4e24\u5927\u5de8\u5934\u2014\u2014\u8bfa\u548c\u8bfa\u5fb7\u548c\u793c\u6765\u3002<\/p>\n<p>\u5229\u62c9\u9c81\u80bd\u662f\u8bfa\u548c\u8bfa\u5fb7\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u5c06GLP-1\u4e0e\u767d\u86cb\u767d\u7ed3\u5408\u7814\u53d1\u51fa\u6765\u7684\u836f\u7269\uff0c\u5b83\u6210\u529f\u5b9e\u73b0\u4e86\u201c\u62b5\u6297DPP-4\u964d\u89e3\u201d\uff0c\u5728\u4eba\u4f53\u5185\u7684\u534a\u8870\u671f\u8fbe\u5230\u4e8613\u5c0f\u65f6\u5de6\u53f3\uff0c\u53ef\u4ee5\u6bcf\u5929\u7ed9\u836f\u4e00\u6b21\u3002<\/p>\n<p>\u5c3d\u7ba1\u5229\u62c9\u9c81\u80bd\u6709\u7740\u8bf8\u591a\u4f18\u70b9\uff0c\u4f46\u662f\u5176\u6bcf\u65e5\u4e00\u6b21\u7684\u9891\u7387\u8fc7\u4e8e\u9891\u7e41\u3002<\/p>\n<p>\u7ade\u4e89\u5bf9\u624b\u793c\u6765\u770b\u5230\u4e86\u8fd9\u4e00\u7a81\u7834\u53e3\uff0c\u4e8e\u662f\u4ed6\u4eec\u901a\u8fc7\u5c06GLP-1\u7c7b\u4f3c\u7269\u5076\u8054\u5230lgG4-Fc\uff08\u4eba\u514d\u75ab\u7403\u86cb\u767dG4 Fc\u7247\u6bb5\uff09\u4e0a\uff0c\u5f97\u5230\u4e86\u5ea6\u62c9\u7cd6\u80bd\uff0c\u5b9e\u73b0\u4e86\u6bcf\u5468\u4e00\u6b21\u7684\u7ed9\u836f\u3002\u5ea6\u62c9\u7cd6\u80bd\u7684\u964d\u7cd6\u6548\u679c\u548c\u5229\u62c9\u9c81\u80bd\u4e0d\u76f8\u4e0a\u4e0b\uff0c\u4f46\u662f\u5728\u51cf\u91cd\u6548\u679c\u4e0a\u5374\u4e0d\u5982\u5229\u62c9\u9c81\u80bd\uff0c\u8fd9\u4e5f\u662f\u5b83\u6ca1\u6709\u7533\u8bf7\u51cf\u80a5\u9002\u5e94\u75c7\u7684\u539f\u56e0\u3002<\/p>\n<p>\u5728\u5ea6\u62c9\u7cd6\u80bd\u9762\u4e16\u4e4b\u540e\uff0c\u8bfa\u548c\u8bfa\u5fb7\u79ef\u6781\u8fce\u6218\u3002<\/p>\n<p>\u4ed6\u4eec\u901a\u8fc7\u5f15\u5165PEG\u57fa\u56e2\u3001\u5e76\u5728\u8102\u80aa\u94fe\u7aef\u5f15\u5165\u989d\u5916\u7fa7\u57fa\u7684\u65b9\u5f0f\uff0c\u7814\u53d1\u51fa\u4e86\u53f8\u7f8e\u683c\u9c81\u80bd\u3002<\/p>\n<p>\u53f8\u7f8e\u683c\u9c81\u80bd\u4e0d\u4ec5\u5b9e\u73b0\u4e86\u6bcf\u5468\u4e00\u6b21\u7ed9\u836f\uff0c\u517668\u5468\u964d\u4f53\u91cd\u7684\u6548\u679c\u66f4\u662f\u8fbe\u5230\u4e8612.7kg\uff0812.4%\uff09\uff0c\u8fd8\u5177\u6709\u660e\u663e\u7684\u5fc3\u8840\u7ba1\u53ca\u80be\u810f\u83b7\u76ca\u7597\u6548\u3002\u5728\u5f88\u957f\u4e00\u6bb5\u65f6\u95f4\u4e4b\u5185\uff0c\u53f8\u7f8e\u683c\u9c81\u80bd\u88ab\u8ba4\u4e3a\u662fGLP-1\u8d5b\u9053\uff0c\u751a\u81f32\u578b\u7cd6\u5c3f\u75c5\u548c\u51cf\u80a5\u8d5b\u9053\u7684\u7ec8\u6781\u4ea7\u54c1\u3002<\/p>\n<p>\u9762\u5bf9\u201c\u795e\u836f\u201d\u53f8\u7f8e\u683c\u9c81\u80bd\u7684\u538b\u529b\uff0c\u793c\u6765\u5f00\u59cb\u4e86\u5927\u53cd\u51fb\u3002<\/p>\n<p>2018\u5e74\u4e4b\u524d\uff0c\u5e38\u89c4\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u90fd\u662f\u4f5c\u7528\u4e8eGLP-1R\uff08GLP-1 Receptor\uff0cGLP-1\u53d7\u4f53\uff09\u8fd9\u4e2a\u5355\u4e00\u7684\u9776\u70b9\uff0c\u80fd\u4e0d\u80fd\u5728GLP-1R\u4e4b\u4f59\uff0c\u518d\u627e\u5230\u4e00\u4e2a\u9776\u70b9\u548cGLP-1R\u5171\u540c\u53d1\u6325\u4f5c\u7528\uff0c\u8ba9\u964d\u7cd6\u51cf\u80a5\u7684\u4f5c\u7528\u6700\u5927\u5316\u5462\uff1f<\/p>\n<p>\u6700\u7ec8\uff0c\u5229\u6765\u627e\u5230\u4e86GIPR\u9776\u70b9\uff08GIP Receptor\uff0c\u7b80\u79f0GIPR\uff09\u3002<\/p>\n<p>\u524d\u6587\u4e2d\u63d0\u5230\uff0c\u80a0\u4fc3\u80f0\u5c9b\u7d20\u4e3b\u8981\u5305\u542b\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\u4fc3\u80f0\u5c9b\u7d20\u80bd\uff08GIP\uff09\u548c\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd\uff08GLP-1\uff09\uff0c\u8fd9\u4e24\u79cd\u6fc0\u7d20\u90fd\u5177\u6709\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\uff0c\u5171\u540c\u4ea7\u751f\u80a0\u4fc3\u80f0\u5c9b\u7d20\u6548\u5e94\u3002<\/p>\n<p>GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u5728\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u9886\u57df\u53d6\u5f97\u4e86\u5de8\u5927\u6210\u529f\uff0c\u4f46\u662fGIP\u53d7\u4f53\u6fc0\u52a8\u5242\u5728\u5f88\u957f\u4e00\u6bb5\u65f6\u95f4\u5185\u5374\u65e0\u4eba\u95ee\u6d25\u3002\u5176\u4e2d\u539f\u56e0\u4e0d\u4ec5\u4e0eGIP\u53d7\u4f53\u6fc0\u52a8\u5242\u4f1a\u523a\u6fc0\u80f0\u9ad8\u8840\u7cd6\u7d20\u5206\u6ccc\u4f7f\u5f97\u8840\u7cd6\u5347\u9ad8\u6709\u5173\uff0c\u66f4\u56e0\u4e3a\u5f53\u65f6\u7684\u7814\u7a76\u8ba4\u4e3a\uff0cGIPR\u4f1a\u76f4\u63a5\u4f5c\u7528\u4e8e\u8102\u80aa\u7ec4\u7ec7\u5bfc\u81f4\u53d1\u80d6\u3002<\/p>\n<p>\u4f46\u662f\uff0c\u5f53\u8fd9\u4e00\u53d7\u4f53\u4e0eGLP-1R\u8054\u5408\u53d1\u6325\u4f5c\u7528\uff0c\u5947\u5999\u7684\u73b0\u8c61\u53d1\u751f\u4e86\u3002<\/p>\n<p>\u793c\u6765\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u5f53\u5355\u7528GIP\u53d7\u4f53\u6fc0\u52a8\u5242\u65f6\uff0c\u80f0\u9ad8\u8840\u7cd6\u7d20\u5bf9\u03b2\u7ec6\u80de\u7684\u80a0\u4fc3\u80f0\u5c9b\u7d20\u4f5c\u7528\u53ef\u4ee5\u964d\u4f4e\u8840\u7cd6\uff1b\u5f53GIP\u53d7\u4f53\u6fc0\u52a8\u5242\u4e0eGLP\uff0d1\u53d7\u4f53\u6fc0\u52a8\u5242\u5408\u7528\u65f6\uff0c\u53ef\u5728\u51cf\u8f7b\u4f53\u91cd\u65b9\u9762\u4ea7\u751f\u76f8\u52a0\u6216\u534f\u540c\u4f5c\u7528\u3002<\/p>\n<p>\u7531\u6b64\uff0c\u793c\u6765\u7814\u53d1\u51fa\u4e86\u66ff\u5c14\u6cca\u80bd\uff08Tirzepatide\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u4f5c\u7528\u4e8eGLP-1R\u548cGIPR\u53cc\u9776\u70b9\u7684\u836f\u7269\uff0c\u901a\u8fc7\u6fc0\u6d3bGLP-1R\u548cGIPR\u8fbe\u5230\u63a7\u5236\u8840\u7cd6\u3001\u8c03\u8282\u4f53\u91cd\u7684\u76ee\u7684\u3002<\/p>\n<p>2019\u5e74\u5e95\uff0c\u793c\u6765\u5bf9\u66ff\u5c14\u6cca\u80bd\u8fdb\u884c\u4e86\u7684SURMOUNT-1\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p>\u7ed3\u679c\u663e\u793a\uff0c\u57282539\u540d\u53d7\u8bd5\u8005\u4e2d\uff0c\u6bcf\u5468\u4e00\u6b21\u7ed9\u836f5mg\u7684\u53d7\u8bd5\u8005\u7b2c72\u5468\u7684\u4f53\u91cd\u5e73\u5747\u964d\u4f4e\u4e8615%\uff1b\u6bcf\u5468\u4e00\u6b21\u7ed9\u836f10mg\u7684\u53d7\u8bd5\u8005\u4f53\u91cd\u5e73\u5747\u964d\u4f4e\u4e8619.5%\uff1b\u6bcf\u5468\u4e00\u6b21\u7ed9\u836f15mg\u7684\u53d7\u8bd5\u8005\u4f53\u91cd\u5e73\u5747\u964d\u4f4e\u4e8620.9%\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u7684\u53d7\u8bd5\u8005\u4f53\u91cd\u5e73\u5747\u964d\u4f4e\u4e863.1%\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/www.idea2003.com\/wp-content\/uploads\/2023-07-13\/c6d448260a9f988eb1146081dfa3b44e.png.jpeg\" alt=\"\u56fe\u7247\" title=\"\u4e0d\u8fd0\u52a8\u4e5f\u80fd\u7626\uff0c\u9a6c\u65af\u514b\u90fd\u5728\u7528\u7684\u51cf\u80a5\u795e\u836f\u662f\u4ec0\u4e48\u6765\u5934\uff1f\u63d2\u56fe6\" \/><\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aNEJM \u300aTirzepatide Once Weekly for the Treatment of Obesity\u300b<\/p>\n<p>\u51e0\u4e4e\u5b8c\u7f8e\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u8ba9\u793c\u6765\u8d81\u70ed\u6253\u94c1\uff0c\u53c8\u5f00\u5c55\u4e86\u4e0e\u53f8\u7f8e\u683c\u9c81\u80bd\u7684\u5934\u5bf9\u5934\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p>\u7ed3\u679c\u663e\u793a\uff0c\u66ff\u5c14\u6cca\u80bd10mg\u548c15mg\u4e0e\u53f8\u7f8e\u683c\u9c81\u80bd2mg\u76f8\u6bd4\uff0c\u53d7\u8bd5\u8005\u7684\u4f53\u91cd\u6709\u66f4\u660e\u663e\u7684\u964d\u4f4e\u3002\u4eca\u5e74\u56db\u6708\uff0c\u793c\u6765\u53c8\u516c\u5e03\u4e86\u66ff\u5c14\u6cca\u80bd\u9488\u5bf9\u80a5\u80d6\u75c7\u76843\u671f\u4e34\u5e8a SURMOUNT-2\u8bd5\u9a8c\uff0c\u7ed3\u679c\u663e\u793a\uff0c15mg\u9ad8\u5242\u91cf\u66ff\u5c14\u6cca\u80bd\u572872\u5468\u5b9e\u73b015.7%\u7684\u51cf\u91cd\u6548\u679c\uff0c\u5373\u5728\u57fa\u7ebf100.7kg\u7684\u4f53\u91cd\u4e0b\u51cf\u91cd15.6kg\u3002<\/p>\n<p>2022\u5e745\u670813\u65e5\uff0c\u66ff\u5c14\u6cca\u80bd\u88abFDA\u6279\u51c6\u4e0a\u5e02\u3002\u5728\u8f85\u52a9\u996e\u98df\u548c\u8fd0\u52a8\u7684\u540c\u65f6\uff0cTirzepatide\u6bcf\u5468\u4ec5\u9700\u6ce8\u5c04\u4e00\u6b21\uff0c\u5c31\u53ef\u4ee5\u6539\u5584\u6210\u4eba2\u578b\u7cd6\u5c3f\u75c5 \uff08T2DM\uff09 \u60a3\u8005\u7684\u8840\u7cd6\u63a7\u5236\u3002\u4e5f\u56e0\u6b64\uff0c\u66ff\u5c14\u6cca\u80bd\u836f\u7269Mounjaro\u4e00\u4e0a\u5e02\u5c31\u5728\u7f8e\u56fd\u8d70\u7ea2\uff0c\u5176\u706b\u7206\u7a0b\u5ea6\u751a\u81f3\u8d85\u8fc7\u4e86\u8bfa\u548c\u8bfa\u5fb7\u7528\u4e8e\u51cf\u80a5\u7684Wegovy\u3002<\/p>\n<p>\u8fd9\u8fd8\u6ca1\u5b8c\uff0c\u5728\u521a\u521a\u7ed3\u675f\u7684ADA2023\u5e74\u4f1a\u4e0a\uff0c\u793c\u6765\u66f4\u662f\u796d\u51fa\u5927\u6740\u5668\u2014\u2014\u4ed6\u4eec\u6b63\u5f0f\u516c\u5e03\u4e86\u5176GCGR\/GIPR\/GLP-1R\u4e09\u91cd\u6fc0\u52a8\u5242Retatrutide\u3002\u8be5\u6fc0\u52a8\u5242\u4f5c\u7528\u4e8eGCGR\u3001GIPR\u3001GLP-1R\u4e09\u4e2a\u9776\u70b9\u4e4b\u4e0a\uff0c\u80fd\u591f\u5b9e\u73b0\u6bd4\u539f\u6709\u53cc\u9776\u70b9\u6fc0\u52a8\u5242\u66f4\u5f3a\u7684\u51cf\u80a5\u6548\u679c\u3002<\/p>\n<p>\u6700\u65b0\u7684\u4e34\u5e8a\u7814\u7a76\u8bba\u6587\u663e\u793a\uff0c\u572848\u5468\u7684\u6cbb\u7597\u65f6\u95f4\u5185\uff0cGCGR\/GIPR\/GLP-1R\u4e09\u91cd\u6fc0\u52a8\u5242Retatrutide\u5728\u6bcf\u546812mg\u7684\u5242\u91cf\u6cbb\u7597\u4e0b\uff0c\u5e2e\u52a9\u80a5\u80d6\u8005\u4f53\u91cd\u51cf\u8f7b\u4e8624.2%\uff0c\u8fd9\u662f\u8fc4\u4eca\u4e3a\u6b62\u836f\u7269\u51cf\u80a5\u5b9e\u73b0\u7684\u6700\u597d\u6548\u679c\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/www.idea2003.com\/wp-content\/uploads\/2023-07-13\/d39b45696ab603a301c763aadc4dba97.jpg\" alt=\"\u56fe\u7247\" title=\"\u4e0d\u8fd0\u52a8\u4e5f\u80fd\u7626\uff0c\u9a6c\u65af\u514b\u90fd\u5728\u7528\u7684\u51cf\u80a5\u795e\u836f\u662f\u4ec0\u4e48\u6765\u5934\uff1f\u63d2\u56fe7\" \/><\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aADA 2023<\/p>\n<p>\u5728\u516c\u5e03\u51cf\u80a5\u6548\u679c\u6570\u636e\u4e4b\u5916\uff0c\u793c\u6765\u8fd8\u516c\u5e03\u4e86Retatrutide\u5bf9NASH(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d)\u7684\u6cbb\u7597\u6570\u636e\uff1a\u7ed3\u679c\u663e\u793a\uff0cRetatrutide\u57288mg\u548c12mg\u6cbb\u7597\u5242\u91cf\u4e0b\uff0c\u60a3\u8005\u5e73\u5747\u76f8\u5bf9\u809d\u810f\u51cf\u8102\u7387\u5927\u4e8e80%\uff0c\u51cf\u8102\u7387\u5927\u4e8e\u7b49\u4e8e70%\u7684\u60a3\u8005\u5360\u6bd4\u8d85\u8fc780%\uff0c48\u5468\u65f6\u8d85\u8fc785%\u7684\u60a3\u8005\u809d\u810f\u8102\u80aa\u53d8\u6027\u6d88\u5931\u3002<\/p>\n<p>\u9664\u4e86\u9488\u5242\uff0c\u5728\u53e3\u670d\u9886\u57df\uff0c\u793c\u6765\u4e0e\u8bfa\u548c\u8bfa\u5fb7\u4e5f\u4e00\u76f4\u5728\u89d2\u9010\u3002<\/p>\n<p>\u4eca\u5e745\u670822\u65e5\uff0c\u8bfa\u548c\u8bfa\u5fb7\u516c\u5e03\u4e86\u5176\u53e3\u670d\u53f8\u7f8e\u683c\u9c81\u80bd\u836f\u7269OASIS 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