8\u670822-23\u65e5\uff0c2023 DEMO WORLD\u4f01\u4e1a\u5f00\u653e\u5f0f\u521b\u65b0\u5927\u4f1a\u5728\u957f\u4e09\u89d2G60\u79d1\u521b\u8d70\u5eca\u7b56\u6e90\u5730\u677e\u6c5f\u9686\u91cd\u4e3e\u884c\u3002\u672c\u5c4a\u5927\u4f1a\u7531\u5fae\u65b0\u521b\u60f3\u4e3b\u529e\uff0c\u677e\u6c5f\u533a\u7ecf\u6d4e\u59d4\u5458\u4f1a\u3001\u677e\u6c5f\u533a\u6295\u8d44\u4fc3\u8fdb\u670d\u52a1\u4e2d\u5fc3\u3001\u56fd\u5bb6\u7ea7\u4e0a\u6d77\u677e\u6c5f\u7ecf\u6d4e\u6280\u672f\u5f00\u53d1\u533a\u3001\u677e\u6c5f\u533a\u6cd7\u6cfe\u9547\u4eba\u6c11\u653f\u5e9c\u3001\u677e\u6c5f\u533a\u4f58\u5c71\u9547\u4eba\u6c11\u653f\u5e9c\u534f\u529e\u3002<\/p>\n
\u5927\u4f1a\u4ee5\u201c\u62e5\u62b1\u5f00\u653e\u201d\u4e3a\u4e3b\u9898\uff0c\u9080\u8bf7200+\u8de8\u56fd\u516c\u53f8\u53ca\u672c\u571f\u4f01\u4e1a\u521b\u65b0\u9886\u8896\uff0c\u805a\u7126\u5f00\u653e\u5f0f\u521b\u65b0\uff0c\u901a\u8fc7\u6f14\u8bb2\u5206\u4eab\u3001\u62a5\u544a\u53d1\u5e03\u3001\u699c\u5355\u8bc4\u9009\u3001\u6848\u4f8b\u5c55\u793a\u3001\u9700\u6c42\u5bf9\u63a5\u7b49\u591a\u79cd\u65b9\u5f0f\uff0c\u63a8\u52a8\u5168\u7403\u521b\u65b0\u8d44\u6e90\u5728\u884c\u4e1a\u4e2d\u7684\u6d41\u52a8\uff0c\u52a0\u901f\u4e16\u754c\u5404\u5730\u7684\u4f01\u4e1a\u5728\u4e2d\u56fd\u6210\u957f\u3002<\/p>\n<\/p>\n
\u4f1a\u4e0a\uff0c\u590d\u5b8f\u6c49\u9716\u9996\u5e2d\u5546\u52a1\u53d1\u5c55\u5b98\u3001\u5546\u52a1\u62d3\u5c55\u526f\u603b\u88c1<\/strong>\u66f9\u5e73<\/strong>\u53d1\u8868\u4e86\u540d\u4e3a\u300a\u672c\u571f\u521b\u65b0\u836f\u4f01\u7684\u786c\u6838\u65f6\u523b\u300b<\/strong>\u7684\u4e3b\u9898\u6f14\u8bb2\uff0c\u7cbe\u5f69\u89c2\u70b9\u5982\u4e0b\uff1a<\/p>\n 1. \u5f53\u6211\u4eec\u8c08\u53ca\u4f01\u4e1a\u7684\u521b\u65b0\u201c\u786c\u6838\u65f6\u523b\u201d\u65f6\uff0c\u610f\u5473\u7740\u8981\u5c06\u4f01\u4e1a\u521b\u65b0\u4f5c\u4e3a\u57fa\u77f3\uff0c\u540c\u65f6\u4ee5\u793e\u4f1a\u8d23\u4efb\u611f\u4f5c\u4e3a\u6838\u5fc3\u76ee\u6807\u3002<\/p>\n 2. \u65e0\u8bba\u4f01\u4e1a\u662f\u505aout-licensing\uff0c\u8fd8\u662fin-licensing\uff0c\u9996\u5148\u8981\u610f\u8bc6\u5230\u4f60\u7684\u6574\u4f53\u4ef7\u503c\uff0c\u5176\u4e2d\u4f01\u4e1a\u6700\u91cd\u8981\u7684\u4ef7\u503c\u662f\u4f60\u7684\u56e2\u961f\u7ba1\u7406\u548c\u4eba\u624d\u3002<\/p>\n 3. \u4ea4\u6613\u6216\u8c08\u5224\uff0c\u5173\u952e\u4e0d\u5728\u4e8e\u4f60\u60f3\u8981\u4ec0\u4e48\uff0c\u800c\u662f\u5728\u4e8e\u7406\u89e3\u5bf9\u65b9\u5728\u610f\u4ec0\u4e48\uff0c\u5e76\u9488\u5bf9\u5bf9\u65b9\u7684\u9700\u6c42\u548c\u987e\u8651\uff0c\u63d0\u4f9b\u89e3\u51b3\u65b9\u6848\uff0c\u4ece\u800c\u4e3a\u53cc\u65b9\u521b\u9020\u4ef7\u503c\u3002<\/p>\n \u4ee5\u4e0b\u4e3a\u6f14\u8bb2\u5185\u5bb9\uff0c\u7531\u5fae\u65b0\u521b\u60f3\u6574\u7406\uff1a <\/p>\n \u611f\u8c22\u4e3b\u529e\u65b9\u7684\u9080\u8bf7\uff0c\u4eca\u5929\u6211\u5c06\u5c31\u533b\u836f\u521b\u65b0\u548c\u56fd\u9645\u5546\u52a1\u62d3\u5c55\u65b9\u9762\uff0c\u5206\u4eab\u590d\u5b8f\u6c49\u9716\u7684\u4f53\u4f1a\u548c\u7ecf\u9a8c\u3002<\/p>\n \u5148\u505a\u4e00\u4e0b\u7b80\u5355\u7684\u81ea\u6211\u4ecb\u7ecd\uff0c\u6211\u52a0\u5165\u590d\u5b8f\u6c49\u97165\u5e74\u4e86\uff0c\u5728\u6b64\u671f\u95f4\uff0c\u4ece\u96f6\u5f00\u59cb\uff0c\u521b\u5efa\u4e86\u590d\u5b8f\u6c49\u9716\u5546\u52a1\u62d3\u5c55\u56e2\u961f\uff0c\u6db5\u76d6\u4e86in-licensing\u3001out-licensing\u548cstrategic alliance\u3002\u4e4b\u524d\uff0c\u6211\u5728\u65bd\u8d35\u5b9d\u5de5\u4f5c\u4e868\u5e74\uff0c\u4e3b\u8981\u4ece\u4e8b\u5546\u52a1\u62d3\u5c55\u3002<\/p>\n \u4eca\u5929\u6211\u7684\u4e3b\u9898\u805a\u7126\u201c\u786c\u6838\u201d\u3002\u5f53\u6211\u4eec\u8c08\u53ca\u4f01\u4e1a\u7684\u521b\u65b0\u201c\u786c\u6838\u65f6\u523b\u201d\u65f6\uff0c\u610f\u5473\u7740\u8981\u5c06\u4f01\u4e1a\u521b\u65b0\u4f5c\u4e3a\u57fa\u77f3\uff0c\u540c\u65f6\u4ee5\u793e\u4f1a\u8d23\u4efb\u611f\u4f5c\u4e3a\u6838\u5fc3\u76ee\u6807\u3002<\/p>\n \u5bf9\u533b\u836f\u516c\u53f8\u800c\u8a00\uff0c\u5982\u679c\u7814\u53d1\u7684\u836f\u7269\u65e0\u6cd5\u88ab\u6c11\u4f17\u5e7f\u6cdb\u627f\u53d7\uff0c\u518d\u51fa\u8272\u4e5f\u96be\u4ee5\u9020\u798f\u5927\u4f17\u3002\u56e0\u6b64\uff0c13\u5e74\u524d\u590d\u5b8f\u6c49\u9716\u6210\u7acb\u4e4b\u521d\uff0c\u5c31\u786e\u7acb\u4e86\u8fd9\u4e00\u4f7f\u547d\uff1a\u6301\u7eed\u521b\u65b0\uff0c\u5353\u8d8a\u8fd0\u8425\uff1b\u4ee5\u4f18\u8d28\u751f\u7269\u836f\uff0c\u9020\u798f\u5168\u7403\u75c5\u60a3\u3002<\/p>\n \u521b\u65b0\u836f\u7814\u53d1\u662f\u4e00\u9879\u9ad8\u98ce\u9669\u3001\u9ad8\u6295\u5165\u3001\u957f\u5468\u671f\u7684\u4e8b\u4e1a\u3002\u901a\u5e38\u6765\u8bf4\uff0c\u521b\u65b0\u836f\u4ece\u7814\u53d1\u5230\u83b7\u6279\u4e0a\u5e02\u9700\u8981\u8fd113\u5e74\u7684\u65f6\u95f4\uff0c\u8017\u8d39\u9ad8\u8fbe15\u4ebf\u7f8e\u5143\uff0c\u5176\u4e2d\uff0c\u80bf\u7624\u836f\u7269\u5f00\u53d1\u6210\u529f\u7387\u4ec55.3%\u3002<\/p>\n \u521b\u65b0\u836f\u4e3b\u8981\u5206\u4e3a\u54ea\u51e0\u7c7b\u521b\u65b0\uff1f\u4e00\u662f\u673a\u5236<\/strong>\u521b\u65b0\uff0c<\/strong>\u6db5\u76d6\u65b0\u901a\u8def\u3001\u9776\u70b9\u53d1\u73b0\uff0c\u9776\u70b9\u4f18\u5316\u548c\u6297\u836f\u6027\u6539\u5584\uff1b<\/p>\n \u4e8c\u662f\u6280\u672f\u521b\u65b0<\/strong>\uff0c\u5305\u62ec\u9776\u70b9\u6280\u672f\u5347\u7ea7\uff0c\u5982\u4ece\u5c0f\u5206\u5b50\u8fc1\u79fb\u5230\u5927\u5206\u5b50\u3001CAR-T\u7b49\uff1b\u5242\u578b\u7684\u521b\u65b0\uff0c\u901a\u8fc7\u4e0d\u540c\u7684\u836f\u7269\u4f20\u9012\u624b\u6bb5\u6539\u5584\u7ed9\u836f\u9891\u7387\uff0c\u63d0\u5347\u7597\u6548\u3002\u8fd9\u4e9b\u662f\u4e2d\u56fd\u4f01\u4e1a\u7684\u7279\u957f\uff0c\u5305\u62ec\u590d\u5b8f\u6c49\u9716\u5728\u5185\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd1\u5e74\u6765\u4e2d\u56fd\u521b\u65b0\u836f\u4f01\u4e1a\u5728\u653f\u5e9c\u548c\u56fd\u5bb6\u652f\u6301\u4e0b\u8fc5\u901f\u589e\u957f\uff0c\u5c55\u73b0\u5f3a\u5927\u6d3b\u529b\u3002<\/p>\n \u4e09\u662f<\/strong>\u4e34\u5e8a\u65b9\u9762\u7684\u8bbe\u8ba1\u4e0e\u521b\u65b0<\/strong>\u3002\u8bb8\u591a\u836f\u7269\u5728\u5dee\u5f02\u5316\u9002\u5e94\u75c7\u4e0a\u6709\u7740\u6f5c\u529b\uff0c\u540c\u65f6\u501f\u52a9\u751f\u7269\u6807\u5fd7\u7269\uff08biomarker\uff09\u7684\u5f15\u5165\uff0c\u7cbe\u51c6\u5730\u9488\u5bf9\u7279\u5b9a\u7fa4\u4f53\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8bbe\u8ba1\uff0c\u5df2\u7ecf\u6210\u4e3a\u8bb8\u591a\u4f01\u4e1a\u521b\u65b0\u7684\u7126\u70b9\u4e4b\u4e00\u3002<\/p>\n \u63a5\u4e0b\u6765\uff0c\u8ba9\u6211\u4eec\u900f\u8fc7\u6570\u636e\uff0c\u770b\u4e00\u4e0b\u8fc7\u53bb5\u5e74\u4e2d\u56fd\u521b\u65b0\u836f\u7684\u53d1\u5c55\u60c5\u51b5\uff1a\u5728IND\u7533\u8bf7\u6570\u91cf\u65b9\u9762\uff0c\u56fd\u4ea7\u4ea7\u54c1\u8fdc\u8fdc\u8d85\u8fc7\u4e86\u8fdb\u53e3\u836f\u7269\u3002\u7136\u800c\uff0cNDA\u7533\u8bf7\u6570\u91cf\uff0c\u5373\u4e0a\u5e02\u7533\u62a5\uff0c\u56fd\u4ea7\u836f\u7269\u7684\u6570\u91cf\u4ecd\u7136\u8fdc\u4e0d\u53ca\u8fdb\u53e3\u836f\u7269\u3002<\/p>\n \u6b64\u5916\uff0c\u6211\u4eec\u53d1\u73b0\u4e00\u4e2a\u660e\u663e\u7684\u8d8b\u52bf\uff1a\u66f4\u591a\u7684\u4e2d\u56fd\u4f01\u4e1a\u5f00\u542f\u5173\u952e\u7684\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c\uff0c\u5176\u6570\u91cf\u5df2\u7ecf\u63a5\u8fd1\u7f8e\u56fd\u3002\u8fd9\u4e00\u70b9\u65e0\u7591\u4ee4\u4eba\u8d5e\u53f9\uff0c\u56e0\u4e3a\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c\u7684\u6295\u5165\u53ca\u98ce\u9669\u662f\u76f8\u5f53\u5927\u7684\u3002 \u7531\u4e8e\u653f\u5e9c\u548c\u56fd\u5bb6\u5c42\u9762\u7684\u5f3a\u529b\u652f\u6301\uff0c\u521b\u65b0\u836f\u5448\u73b0\u51fa\u4e86\u7206\u53d1\u5f0f\u7684\u589e\u957f\u6001\u52bf\u3002<\/p>\n \u4e8b\u5b9e\u4e0a\uff0c\u5927\u591a\u6570\u9776\u70b9\u4ecd\u7136\u96c6\u4e2d\u5728\u6210\u719f\u9886\u57df\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u670949%\u7684\u9776\u70b9\u90fd\u662f\u56fd\u5916\u4f01\u4e1a\u5df2\u7ecf\u9a8c\u8bc1\u8fc7\u7684\uff0c\u8fd9\u79cd\u8ddf\u968f\u7684\u7b56\u7565\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u964d\u4f4e\u4e86\u7814\u53d1\u7684\u98ce\u9669\uff0c\u540c\u65f6\u5728\u6280\u672f\u5c42\u9762\u7684\u521b\u65b0\u6709\u6240\u7a81\u7834\uff0c\u5982\u5206\u5b50\u7ed3\u6784\u3001\u6a21\u5f0f\u9009\u62e9\u4ee5\u53ca\u6297\u4f53\u5f00\u53d1\uff0c\u8fd8\u5305\u62ec\u6297\u6bd2\u6027\u63aa\u65bd\u7b49\u2026\u2026\u8fd9\u7c7b\u521b\u65b0\u4e5f\u4f7f\u5f97\u4e2d\u56fd\u836f\u4f01\u5728\u5168\u7403\u8303\u56f4\u5185\u7684\u665a\u671f\u4ea7\u54c1\u4e2d\u9010\u6e10\u5d2d\u9732\u5934\u89d2\u3002<\/p>\n \u65e0\u7591\u4e2d\u56fd\u836f\u4f01\u5728\u521b\u65b0\u65b9\u9762\u4ecd\u6709\u5f88\u5927\u7684\u53d1\u5c55\u7a7a\u95f4\uff1a\u6570\u636e\u663e\u793a\uff0c\u4ecd\u6709865\u4e2a\u9776\u70b9\u81f3\u4eca\u672a\u5f97\u5230\u5145\u5206\u5173\u6ce8\u3002\u6ca1\u6709\u9a8c\u8bc1\u8fc7\u7684\u9776\u70b9\u5c31\u610f\u5473\u7740\u66f4\u9ad8\u7684\u98ce\u9669\u4e0e\u6311\u6218\u3002\u5e0c\u671b\u4eca\u540e\u7684\u51e0\u5e74\uff0c\u4f1a\u6709\u66f4\u591a\u7684\u4e2d\u56fd\u4f01\u4e1a\u805a\u7126\u65b0\u9776\u70b9\uff0c\u505a\u51fa\u66f4\u591afirst in class\u7684\u521b\u65b0\u4ea7\u54c1\uff1b <\/p>\n 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