\u8fd1\u65e5\uff0c\u65b0\u5143\u7d20\u533b\u836f\u5b8c\u6210\u8d856\u4ebf\u5143\u4eba\u6c11\u5e01\u7684D\u8f6e\u878d\u8d44\u3002\u672c\u8f6e\u878d\u8d44\u7531\u65b0\u8001\u80a1\u4e1c\u5171\u540c\u53c2\u4e0e\uff0c\u7531\u51ef\u6cf0\u8d44\u672c\u9886\u6295\uff0c\u8fbe\u6668\u8d22\u667a\u3001\u534e\u91d1\u6295\u8d44\u3001\u4e7e\u9053\u96c6\u56e2\u3001\u65b0\u6bc5\u6295\u8d44\u7b49\u8ddf\u6295\uff0c\u4e2d\u4fe1\u8bc1\u5238\u3001\u65b9\u5706\u8d44\u672c\u62c5\u4efb\u516c\u53f8\u8d22\u52a1\u987e\u95ee\u3002<\/p>\n
\u672c\u8f6e\u878d\u8d44\u5b8c\u6210\u540e\uff0c\u516c\u53f8\u603b\u878d\u8d44\u7ea612\u4ebf\u5143\u4eba\u6c11\u5e01\u3002\u6b64\u6b21D\u8f6e\u878d\u8d44\u8d44\u91d1\u5c06\u4e3b\u8981\u7528\u4e8e\u5b8c\u6210ABP-671\u5728\u5168\u7403\u53ca\u4e2d\u56fd\u7684\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u4ee5\u53ca\u8fdb\u4e00\u6b65\u63a8\u8fdb\u6cbb\u7597\u708e\u75c7\u548c\u5176\u5b83\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7ba1\u7ebf\u7684\u7814\u53d1\u3002<\/p>\n
\u65b0\u5143\u7d20\u533b\u836f\u662f\u4e00\u5bb6\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u4e13\u6ce8\u4e8e\u4ee3\u8c22\u548c\u708e\u75c7\u9886\u57df\u75be\u75c5\u7684Best-in-Class\u521b\u65b0\u836f\u7684\u7814\u53d1\u3002\u501a\u950b\u8d44\u672c\u66fe\u57282022\u5e74\u521d\u53c2\u4e0e\u65b0\u5143\u7d20\u533b\u836f\u6570\u4ebf\u5143C\u8f6e\u878d\u8d44\u3002<\/strong><\/p>\n \u65b0\u5143\u7d20\u533b\u836f\u76ee\u524d\u5df2\u6709\u591a\u4e2a\u4e0d\u540c\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u524d\u53ca\u4e34\u5e8a\u9636\u6bb5\u3002<\/strong>\u5176\u4e2d\uff0c\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u75db\u98ce\u76841.1\u7c7b\u521b\u65b0\u836fABP-671\u5df2\u5728\u5168\u7403\u5f00\u542f\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/strong>ABP-671\u901a\u8fc7\u6291\u5236\u80be\u810f\u5c3f\u9178\u8f6c\u8fd0\u86cb\u767d1 (URAT1)\uff0c\u4ece\u800c\u4f7f\u5c3f\u6db2\u5c3f\u9178\u76d0\u6b63\u5e38\u6392\u6cc4\uff0c\u8fbe\u5230\u964d\u4f4e\u8840\u6e05\u5c3f\u9178(sUA)\u6c34\u5e73\u7684\u76ee\u7684\uff0c\u5176\u4e34\u5e8a\u4e3b\u8981\u6cbb\u7597\u7ec8\u70b9\u662f\u5c06sUA\u964d\u4f4e\u81f3< 6 mg\/dL (360 \u03bcmol\/L)\u7684\u63a7\u5236\u76ee\u6807\u3002<\/p>\n \u5728\u4e24\u9879\u8bc4\u4f30ABP-671\u4e0d\u540c\u5242\u91cf (\u4ece1 mg\u523012 mg\uff0c\u6bcf\u5929\u5355\u6b21\u7ed9\u836f) \u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cABP-671\u8868\u73b0\u51fa\u826f\u597d\u7684\u836f\u6548\u548c\u5b89\u5168\u6027\u3002\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0cABP-671\u76842 mg\u6bcf\u5929\u5355\u6b21\u7ed9\u836f\uff0c\u5176\u836f\u6548\u53ef\u80fd\u76f8\u5f53\u4e8e\u6216\u4f18\u4e8e\u82ef\u6eb4\u9a6c\u9686\u548c\u975e\u5e03\u53f8\u4ed6\u6700\u9ad8\u5242\u91cf80 mg\u7684\u836f\u6548\u3002ABP-671\u76846 mg\u548c8 mg\u4e24\u4e2a\u5242\u91cf\u7ec4\uff0c100%\u53d7\u8bd5\u8005\u7684sUA\u6c34\u5e73\u8fbe\u5230< 6 mg\/dL \u7684\u4e34\u5e8a\u4e3b\u8981\u6cbb\u7597\u7ec8\u70b9\uff1b\u66f4\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0c100%\u53d7\u8bd5\u8005\u7684sUA\u6c34\u5e73\u8fbe\u5230< 5 mg\/dL (300 \u03bcmol\/L)\uff0c\u4ee5\u53ca\u5206\u522b\u670957%\u53ca87.5%\u4ee5\u4e0a\u53d7\u8bd5\u8005\u7684sUA\u6c34\u5e73\u8fbe\u5230< 4 mg\/dL (240 \u03bcmol\/L)\uff0c\u90e8\u5206\u53d7\u8bd5\u8005\u7684sUA\u6c34\u5e73< 3 mg\/dL (180 \u03bcmol\/L)\u3002ABP-671\u9ad8\u5242\u91cf\u7ec412 mg\u5355\u6b21\u7ed9\u836f\u540e\uff0c100%\u53d7\u8bd5\u8005\u7684sUA\u6c34\u5e73< 4 mg\/dL\u3002ABP-671\u6bcf\u5929\u7ed9\u836f\u4e00\u6b21\uff0c\u836f\u6548\u53ef\u7ef4\u6301\u5168\u5929\u501924\u5c0f\u65f6\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u6ca1\u6709\u51fa\u73b0\u660e\u663e\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002<\/p>\n \u75db\u98ce\u60a3\u8005\u7684\u8840\u5c3f\u9178\u6c34\u5e73\u8fbe\u52305 – 4 mg\/dL\u8303\u56f4\u662f\u8bb8\u591a\u56fd\u5bb6\u75db\u98ce\u6cbb\u7597\u6307\u5357\u6240\u63a8\u8350\u7684\uff0c\u8fd9\u5c06\u6709\u52a9\u4e8e\u60a3\u8005\u75db\u98ce\u77f3\u6eb6\u89e3\uff0c\u51cf\u5c11\u75db\u98ce\u77f3\u5927\u5c0f\u548c\u6570\u91cf\uff0c\u4ee5\u53ca\u964d\u4f4e\u6025\u6027\u75db\u98ce\u53d1\u4f5c\u3002\u8fd9\u662f\u76ee\u524d\u5927\u90e8\u5206\u5e02\u573a\u836f\u7269\u96be\u4ee5\u8fbe\u5230\u7684\u3002ABP-671\u6838\u5fc3\u4e13\u5229\u5df2\u83b7\u5f9770\u4f59\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u7684\u4e13\u5229\u6388\u6743\u3002<\/p>\n 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